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If you've been suffering from depression and anxiety, Zoloft may be an option for you. Zoloft is a selective serotonin reuptake inhibitor lyrica trade (SSRI) which means it works by increasing the level of serotonin, a neurotransmitter that helps regulate mood. This medication has fewer side effects than other antidepressant medications, making it a great choice for many people suffering from depression or anxiety.